Some Thoughts on Bacteria with Arsenic DNA

Word has leaked that today’s press con­fer­ence is about bac­te­ria with DNA that uses arsenic in place of phos­pho­rus in the struc­ture of its DNA.  NASA is fram­ing this has hav­ing broad impli­ca­tions for the search for extrater­res­trial life, but I am won­der­ing about the evo­lu­tion­ary his­tory of such a critter.

Is there an entire par­al­lel evo­lu­tion­ary his­tory, entire groups of species, that have evolved for bil­lions of years to uti­lize arsenic?  Or is this a more rel­a­tively mod­ern tech­nique.   Because it’s not as Earth-​​shattering if these guys turn out to be descen­dants of reg­u­lar DNA struc­ture crit­ters (I’m at a loss for good ter­mi­nol­ogy here.  They’re not arsenic-“based”—they’re still using car­bon as far as I know.)  The impli­ca­tions on the search for extrater­res­trial life is not so great if they still had to evolve under sim­i­lar cir­cum­stances, and this is just a case of reg­u­lar,  store-​​brand life adapt­ing to toxic envi­ron­ments like Mono Lake.  By which I mean, if the con­di­tions were always toxic, it’s pos­si­ble that these bac­te­ria would have never had a chance to evolve in the first place.

Of course, there’s another option to them hav­ing evolved from reg­u­lar DNA-​​based life or even in con­junc­tion over mil­lions and bil­lions of years.  That is, they’re not earth-​​based in ori­gin.  Alien invaders, liv­ing among us!  I sus­pect the early buzz would have an entirely dif­fer­ent tone if that were con­clu­sively the case however.

We’ll learn more at the press con­fer­ence today, I’m sure, and I’m sure they’ve thought through every­thing I’ve just went over.  I look for­ward to more details.  It’s pretty damned excit­ing stuff, but for me it’s just a con­fir­ma­tion of a gen­eral sus­pi­cion, which is that if it’s chem­i­cally pos­si­ble and con­du­sive to self-​​replication, organ­isms will find a way.  The process of evo­lu­tion is like open­ing 10,000 doors simultaneously—I sup­pose it’s inevitable that some of those doors, when not fatally trapped, will lead to some odd places.

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    8 Responses

    1. Tony Noland says:

      As I recall, there are dozens of enzymes devoted to phos­pho­ry­la­tion and dephos­pho­ry­la­tion; if they’ve all adapted to arse­n­a­tion (sp?) and dearsean­tion, that’s a huge set of really inter­est­ing biol­ogy, regard­less of where they came from.

      I’m hop­ing they’ll announce the DNA sequence relat­ed­ness. That’ll help place this bug in rela­tion­ship to the rest of us.

      • Jeremiah Tolbert says:

        Absolutely. I don’t mean to detract. I do want to tamp down a lit­tle bit of the hyperbole.

        • Dale says:

          It is closely related to the gamma-​​proteobacteria, so the trait of arsenic uti­liza­tion is derived rather than ancestral.

          • Jeremiah Tolbert says:

            Ah, good to know, thanks. I sup­pose it was a bit point­less to spec­u­late before the press conference.

    2. Aranea says:

      Here is what I gath­ered from skim­ming through the arti­cle in Science (see link below). These bac­te­ria nor­mally use phos­phor. It’s only when they are grown solely on arsenic that they can incor­po­rate it into their struc­ture. it’s still mon­u­men­tal that we have a life form that can sub­sti­tute an ele­ment that’s part of its DNA. However not as excit­ing for me as if the bac­te­ria was using arsenic as the nat­ural build­ing blog of its DNA.

      http://​www​.sci​encemag​.org/​c​o​n​t​e​n​t​/​e​a​r​l​y​/​2​0​1​0​/​1​2​/​0​1​/​s​c​i​e​n​c​e​.​1​1​9​7​258

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